Regulation of growth hormone receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of growth hormone receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LST1, GPBAR1, and CCL19, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of growth hormone receptor signaling pathway activity versus LST1 in UCEC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LST1 →	+0.833	+0.260	.002	.002	3	5
PDAC	GPBAR1 →	+0.674	+0.469	<.001	.007	3	4
UCEC	CCL19 →	+1.501	+0.247	<.001	.001	3	4
UCEC	TYROBP →	+0.904	+0.251	.003	.001	3	3
BRCA	SASH3 →	+0.658	+0.258	.004	.007	3	3
BRCA	WDFY4 →	+0.508	+0.293	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060398 vs LST1 — UCEC

Explore this scatter interactively →