SMAD protein signal transduction

Across TCGA cell cohorts, RNA activity of the SMAD protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL24, ATP9B, and CLCN7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPL24 grouped by SMAD protein signal transduction-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RPL24 →	+0.668	+0.787	.002	.004	3	4
SOFT_TISSUE	ATP9B →	-0.650	-0.826	.008	.002	3	4
BREAST	CLCN7 →	-0.773	-0.726	<.001	.004	3	3
BREAST	IRF6 →	-2.599	-0.880	.001	.006	3	3
OVARY	APPL2 →	-0.906	-1.244	.006	.002	3	3
BREAST	TMEM63B →	-0.917	-0.921	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPL24 by SMAD protein signal transduction activity — BREAST

Explore this box plot interactively →