Positive regulation of SMAD protein signal transduction

Across TCGA patient cohorts, RNA activity of the Positive regulation of SMAD protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGN2P35, LINC01716, and CALD1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of SMAD protein signal transduction activity versus HMGN2P35 in BRCA (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HMGN2P35 →	-0.334	-0.584	<.001	.001	3	3
LUAD	LINC01716 →	-0.037	-0.449	<.001	.006	3	3
UCEC	CALD1 →	+0.551	+0.464	.003	.003	3	3
LSCC	STX12 →	+0.278	+0.614	.001	<.001	3	3
LSCC	VAMP3 →	+0.205	+0.359	.007	.008	3	3
HNSC	EYA4 →	+0.769	+0.538	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060391 vs HMGN2P35 — BRCA

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