Positive regulation of SMAD protein signal transduction

Across TCGA cell cohorts, RNA activity of the Positive regulation of SMAD protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EEPD1, TBC1D8B, and LRSAM1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EEPD1 grouped by Positive regulation of SMAD protein signal transduction-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	EEPD1 →	+2.756	+0.191	.002	.006	2	6
BONE	TBC1D8B →	-1.165	-0.346	.001	.002	3	4
BONE	LRSAM1 →	+0.844	+0.357	.003	.001	3	4
BONE	OSTM1 →	-1.516	-0.381	.008	<.001	3	4
LUNG_NSCLC_LUAD	IL17RC →	-0.749	-0.252	<.001	.003	3	4
OESOPHAGUS	RBMXL1 →	+1.053	+0.224	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EEPD1 by Positive regulation of SMAD protein signal transduction activity — STOMACH

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