Positive regulation of SMAD protein signal transduction

Across TCGA cell cohorts, RNA activity of the Positive regulation of SMAD protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THBS1, NABP1, and PDXP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of SMAD protein signal transduction activity versus THBS1 in LIVER (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	THBS1 →	-4.381	-0.315	.002	.008	3	6
STOMACH	NABP1 →	-1.566	-0.212	.001	.002	3	6
LUNG_SCLC	PDXP →	+0.826	+0.314	.008	.003	3	6
SKIN	CDC25A →	+0.980	+0.258	.009	.002	3	6
BREAST	FXYD5 →	-3.413	-0.222	<.001	.003	3	5
BLOOD_Leukemia	CD151 →	-1.402	-0.158	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060391 vs THBS1 — LIVER

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