Regulation of SMAD protein signal transduction

Across TCGA patient cohorts, RNA activity of the Regulation of SMAD protein signal transduction pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCL_S795, ZCCHC24, and IGFBP7, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of SMAD protein signal transduction activity versus VCL_S795 in OV (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	VCL_S795 →	+0.813	+0.053	<.001	<.001	3	9
OV	ZCCHC24 →	+0.847	+0.042	<.001	<.001	3	9
PDAC	IGFBP7 →	+0.704	+0.037	<.001	.003	3	9
PDAC	SEPTIN4 →	+0.594	+0.033	<.001	.003	2	9
CCRCC	SERPING1 →	+0.482	+0.055	<.001	<.001	3	8
OV	SORBS1 →	+0.604	+0.048	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060390 vs VCL_S795 — OV

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