Regulation of SMAD protein signal transduction

Across TCGA patient cohorts, RNA activity of the Regulation of SMAD protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDE1A, APOD, and FAM13C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of SMAD protein signal transduction activity versus PDE1A in LSCC (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PDE1A →	+0.491	+0.413	<.001	<.001	3	5
UCEC	APOD →	+1.134	+0.314	.003	.007	3	5
BRCA	FAM13C →	+0.582	+0.791	<.001	<.001	3	5
LSCC	MCM4 →	-0.612	-0.400	<.001	<.001	3	4
CCRCC	ASPA →	+1.130	+0.499	<.001	.001	3	4
LSCC	BICC1 →	+0.552	+0.488	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060390 vs PDE1A — LSCC

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