Axonogenesis involved in innervation

Across TCGA patient cohorts, RNA activity of the Axonogenesis involved in innervation pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD6, TRBV19, and HIBADH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axonogenesis involved in innervation activity versus CD6 in PDAC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CD6 →	+0.449	+0.623	.001	.001	3	4
CCRCC	TRBV19 →	+0.609	+0.411	.005	.003	3	4
LUAD	HIBADH →	-0.466	-0.829	<.001	<.001	3	4
GBM	KLHDC7B →	+0.294	+0.209	.003	.006	3	4
GBM	IL15 →	+0.410	+0.184	.004	.008	3	4
LUAD	IL2RB →	+0.599	+0.847	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060385 vs CD6 — PDAC

Explore this scatter interactively →