Axonogenesis involved in innervation

Across TCGA cell cohorts, RNA activity of the Axonogenesis involved in innervation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPD1L, IGFBP6, and RPS26, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axonogenesis involved in innervation activity versus GPD1L in SKIN (Pearson r = -0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GPD1L →	-1.274	-1.370	<.001	.005	3	5
SKIN	IGFBP6 →	+2.132	+1.842	<.001	<.001	3	4
SKIN	RPS26 →	-0.502	-1.430	.001	.003	3	4
STOMACH	IRF5 →	-2.433	-1.867	.003	<.001	3	4
BREAST	RECQL →	+1.361	+1.113	<.001	.001	3	4
BREAST	DRAP1 →	+1.246	+0.964	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060385 vs GPD1L — SKIN

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