Innervation

Across TCGA patient cohorts, RNA activity of the Innervation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THBS2, COL3A1, and C1S, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Innervation activity versus THBS2 in CCRCC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	THBS2 →	+0.964	+0.045	<.001	<.001	3	8
GBM	COL3A1 →	+0.641	+0.069	<.001	<.001	3	8
PDAC	C1S →	+0.485	+0.059	<.001	<.001	3	8
CCRCC	CLEC3B →	+0.607	+0.039	<.001	<.001	3	8
CCRCC	SULF1 →	+0.963	+0.050	<.001	<.001	3	7
GBM	COL12A1 →	+0.897	+0.072	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060384 vs THBS2 — CCRCC

Explore this scatter interactively →