Innervation

Across TCGA cell cohorts, RNA activity of the Innervation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC89, EGF, and PLPP3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC89 grouped by Innervation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CCDC89 →	-0.995	-1.047	.005	.003	3	4
OESOPHAGUS	EGF →	-1.355	-0.495	.001	.007	3	4
SKIN	PLPP3 →	-1.306	-0.829	.002	.005	3	4
BLOOD_Lymphoma	INPP5J →	-3.082	-1.629	.001	<.001	3	4
LIVER	PRR5 →	-2.580	-1.503	.004	.002	3	4
STOMACH	ARID3A →	-2.514	-1.374	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC89 by Innervation activity — KIDNEY

Explore this box plot interactively →