Innervation

Across TCGA cell cohorts, RNA activity of the Innervation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LOXL2, ADGRL1, and FAM126A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Innervation activity versus LOXL2 in BREAST (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LOXL2 →	+5.021	+1.275	.005	.001	3	5
SKIN	ADGRL1 →	-0.948	-1.427	<.001	<.001	3	4
STOMACH	FAM126A →	+2.711	+1.529	.001	<.001	3	4
BREAST	LGALS1 →	+4.962	+1.178	.001	.004	3	4
BREAST	ECE1 →	+1.659	+1.269	.003	.001	3	4
BREAST	BMP2K →	+1.272	+1.275	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060384 vs LOXL2 — BREAST

Explore this scatter interactively →