Cardiac muscle cell myoblast differentiation

Across TCGA patient cohorts, RNA activity of the Cardiac muscle cell myoblast differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MST1, FMNL3, and PRKD1_S219, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac muscle cell myoblast differentiation activity versus MST1 in BRCA (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MST1 →	+0.500	+0.045	<.001	.001	3	6
PDAC	FMNL3 →	+0.316	+0.055	<.001	.007	3	6
LSCC	PRKD1_S219 →	+0.696	+0.081	<.001	<.001	3	6
BRCA	ASAP1 →	+0.264	+0.057	<.001	<.001	3	5
BRCA	SERPING1 →	+0.562	+0.056	<.001	<.001	3	5
LSCC	C1R →	+0.526	+0.052	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060379 vs MST1 — BRCA

Explore this scatter interactively →