Cardiac muscle cell myoblast differentiation

Across TCGA patient cohorts, RNA activity of the Cardiac muscle cell myoblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCDH18, CALD1, and LRRC32, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac muscle cell myoblast differentiation activity versus PCDH18 in BRCA (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PCDH18 →	+0.633	+0.439	.001	<.001	3	6
BRCA	CALD1 →	+0.750	+0.461	<.001	<.001	3	5
CCRCC	LRRC32 →	+0.742	+0.628	.001	.001	3	5
GBM	PDGFRB →	+0.587	+0.231	<.001	<.001	3	5
BRCA	TGFB3 →	+0.623	+0.313	.004	.007	3	5
BRCA	FBN1 →	+1.250	+0.498	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060379 vs PCDH18 — BRCA

Explore this scatter interactively →