Cardiac muscle cell myoblast differentiation

Across TCGA cell cohorts, RNA activity of the Cardiac muscle cell myoblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC5A1, TTLL12, and KLC3, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac muscle cell myoblast differentiation activity versus SLC5A1 in CNS (Pearson r = -0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SLC5A1 →	-0.054	-0.379	.003	<.001	3	1
CNS	TTLL12 →	-0.530	-0.379	.006	<.001	3	1
CNS	KLC3 →	+0.871	+0.352	.003	.002	3	1
CNS	UBTF →	-0.406	-0.379	.001	<.001	3	1
CNS	VAX2 →	-1.100	-0.477	.005	.001	3	1
CNS	CDKN1A →	+1.873	+0.437	.003	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060379 vs SLC5A1 — CNS

Explore this scatter interactively →