Regulation of ventricular cardiac muscle cell membrane depolarization

Across TCGA cell cohorts, RNA activity of the Regulation of ventricular cardiac muscle cell membrane depolarization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTP4A2, SSBP3, and NAP1L2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTP4A2 grouped by Regulation of ventricular cardiac muscle cell membrane depolarization-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PTP4A2 →	-1.338	-1.409	<.001	<.001	3	4
BLOOD_Leukemia	SSBP3 →	-1.494	-1.063	<.001	.001	3	4
LIVER	NAP1L2 →	+1.363	+1.311	<.001	.002	3	4
KIDNEY	ADAM28 →	-0.721	-1.056	<.001	.005	3	3
URINARY_TRACT	TFEB →	+1.972	+2.034	.006	<.001	3	3
SOFT_TISSUE	SLC25A15 →	+1.011	+1.462	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTP4A2 by Regulation of ventricular cardiac muscle cell membrane depolarization activity — BLOOD_Leukemia

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