Regulation of ventricular cardiac muscle cell membrane depolarization

Across TCGA cell cohorts, RNA activity of the Regulation of ventricular cardiac muscle cell membrane depolarization pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCDHB12, ABR, and IL15, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PCDHB12 grouped by Regulation of ventricular cardiac muscle cell membrane depolarization-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PCDHB12 →	+0.381	+1.730	.007	<.001	3	4
LUNG_SCLC	ABR →	-0.287	-1.303	<.001	<.001	3	4
OVARY	IL15 →	-0.143	-1.095	.007	<.001	3	4
BREAST	FOXA1 →	+0.530	+0.428	<.001	.001	3	3
BONE	CLCF1 →	+0.201	+1.386	.001	<.001	3	3
LIVER	UROS →	-0.270	-2.146	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PCDHB12 by Regulation of ventricular cardiac muscle cell membrane depolarization activity — BONE

Explore this box plot interactively →