Regulation of atrial cardiac muscle cell membrane repolarization

Across TCGA patient cohorts, RNA activity of the Regulation of atrial cardiac muscle cell membrane repolarization pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS2, ZNF704_S77, and TPI1_S80, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of atrial cardiac muscle cell membrane repolarization activity versus RPS2 in HNSC (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPS2 →	+0.177	+0.107	<.001	<.001	3	5
LSCC	ZNF704_S77 →	-0.720	-0.073	.002	.002	3	5
BRCA	TPI1_S80 →	+0.510	+0.076	<.001	<.001	3	5
OV	HOOK2 →	+0.457	+0.115	<.001	<.001	3	5
COAD	NIBAN1_S596 →	+0.793	+0.115	.003	.004	3	4
LSCC	PI3 →	+1.461	+0.082	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060372 vs RPS2 — HNSC

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