Regulation of atrial cardiac muscle cell membrane repolarization

Across TCGA cell cohorts, RNA activity of the Regulation of atrial cardiac muscle cell membrane repolarization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MELTF, TPM2, and YWHAE, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MELTF grouped by Regulation of atrial cardiac muscle cell membrane repolarization-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MELTF →	-1.268	-0.831	.009	.002	3	5
STOMACH	TPM2 →	-4.871	-1.335	<.001	.002	3	5
BREAST	YWHAE →	+0.769	+0.945	<.001	.001	3	5
BREAST	KIAA0753 →	+0.541	+0.793	.002	<.001	3	5
LUNG_NSCLC_LUAD	MXRA7 →	-1.172	-0.837	.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	TMEM53 →	+1.046	+1.191	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MELTF by Regulation of atrial cardiac muscle cell membrane repolarization activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →