Regulation of atrial cardiac muscle cell membrane repolarization

Across TCGA cell cohorts, RNA activity of the Regulation of atrial cardiac muscle cell membrane repolarization pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNAS, COX4I1, and OR52I2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GNAS grouped by Regulation of atrial cardiac muscle cell membrane repolarization-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	GNAS →	-0.246	-0.231	.005	.002	3	5
STOMACH	COX4I1 →	-0.485	-0.356	<.001	<.001	3	5
KIDNEY	OR52I2 →	-0.232	-0.233	.002	.003	3	4
BLOOD_Leukemia	ZNF652 →	-0.233	-0.303	.009	<.001	3	4
SOFT_TISSUE	RALGAPA1P1 →	-0.275	-0.254	.004	.003	3	4
BLOOD_Myeloma	CYP27B1 →	+0.375	+0.458	.008	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GNAS by Regulation of atrial cardiac muscle cell membrane repolarization activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →