Regulation of atrial cardiac muscle cell membrane depolarization

Across TCGA cell cohorts, RNA activity of the Regulation of atrial cardiac muscle cell membrane depolarization pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHLDA1, ZNF354A, and HTR7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PHLDA1 grouped by Regulation of atrial cardiac muscle cell membrane depolarization-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PHLDA1 →	+1.614	+0.989	.009	.007	3	5
URINARY_TRACT	ZNF354A →	+0.951	+1.504	.001	<.001	3	5
CNS	HTR7 →	+1.177	+0.728	.005	.002	3	5
CNS	MMP19 →	+1.731	+1.083	<.001	<.001	3	4
LUNG_SCLC	METRNL →	+2.771	+0.858	<.001	.001	3	4
CNS	CHIC1 →	+0.696	+1.228	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PHLDA1 by Regulation of atrial cardiac muscle cell membrane depolarization activity — LARGE_INTESTINE

Explore this box plot interactively →