Positive regulation of Fc receptor mediated stimulatory signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of Fc receptor mediated stimulatory signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OGFRL1, CD37, and PIP4K2A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of Fc receptor mediated stimulatory signaling pathway activity versus OGFRL1 in BREAST (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OGFRL1 →	+1.761	+0.939	<.001	.004	3	4
BLOOD_Leukemia	CD37 →	+2.591	+0.986	<.001	<.001	3	3
URINARY_TRACT	PIP4K2A →	+2.166	+0.641	<.001	.003	3	3
STOMACH	EPHA1 →	-3.124	-1.189	<.001	.005	3	3
STOMACH	DEPTOR →	+2.262	+1.243	.003	.003	3	3
BLOOD_Myeloma	SMAD1 →	+3.643	+0.539	.002	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060369 vs OGFRL1 — BREAST

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