Regulation of Fc receptor mediated stimulatory signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of Fc receptor mediated stimulatory signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SELL, NCF1B, and ZBP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of Fc receptor mediated stimulatory signaling pathway activity versus SELL in LSCC (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SELL →	+1.204	+0.269	<.001	<.001	3	7
LSCC	NCF1B →	+0.752	+0.283	<.001	<.001	3	6
HNSC	ZBP1 →	+0.862	+0.156	.002	.001	3	6
HNSC	BCL2A1 →	+1.448	+0.275	<.001	<.001	3	6
HNSC	CCR1 →	+1.022	+0.225	<.001	<.001	3	6
HNSC	TRIM22 →	+1.297	+0.194	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060368 vs SELL — LSCC

Explore this scatter interactively →