Regulation of Fc receptor mediated stimulatory signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of Fc receptor mediated stimulatory signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NRP1, BARX1, and PSD, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NRP1 grouped by Regulation of Fc receptor mediated stimulatory signaling pathway-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	NRP1 →	-2.408	-1.551	.003	<.001	3	4
LUNG_NSCLC_LUSC	BARX1 →	-2.344	-1.429	.003	.004	3	4
URINARY_TRACT	PSD →	-0.927	-1.890	.003	<.001	3	4
SKIN	DNAJA1 →	-0.618	-0.808	.001	.007	3	4
SOFT_TISSUE	PTGR2 →	+0.679	+1.189	.006	<.001	3	4
BLOOD_Leukemia	CDC42BPG →	+0.607	+0.917	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NRP1 by Regulation of Fc receptor mediated stimulatory signaling pathway activity — LIVER

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