Regulation of Fc receptor mediated stimulatory signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of Fc receptor mediated stimulatory signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD47, NLRC3, and RBBP4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of Fc receptor mediated stimulatory signaling pathway activity versus CD47 in OVARY (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CD47 →	+1.752	+0.579	.005	.004	3	6
BLOOD_Leukemia	NLRC3 →	+1.320	+0.248	<.001	<.001	3	5
STOMACH	RBBP4 →	+0.938	+1.094	.004	<.001	3	5
BONE	RYBP →	+1.745	+1.622	.005	<.001	3	4
LARGE_INTESTINE	XAF1 →	+2.170	+0.934	.003	.008	3	4
LUNG_SCLC	EPM2A →	+1.000	+0.959	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060368 vs CD47 — OVARY

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