Positive regulation of cell adhesion molecule production

pathway activity — cross-omics
GO:0060355Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell adhesion molecule production pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RETN, ITGAM, and S100A12, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMRETN →+1.435+0.175<.001<.00139
LSCCITGAM →+0.787+0.164<.001<.00139
LSCCS100A12 →+1.480+0.194<.001<.00139
OVKDM5A_S1331 →-0.867-0.132.002<.00139
LSCCMMP9 →+1.100+0.171<.001<.00139
GBMPADI4 →+1.264+0.168<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration