Cell adhesion molecule production

Across TCGA patient cohorts, RNA activity of the Cell adhesion molecule production pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C1R, IKBIP, and C1S, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell adhesion molecule production activity versus C1R in GBM (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	C1R →	+0.552	+0.098	<.001	<.001	3	8
GBM	IKBIP →	+0.619	+0.068	<.001	<.001	3	8
BRCA	C1S →	+0.706	+0.059	<.001	<.001	3	8
BRCA	CFP →	+0.793	+0.062	<.001	<.001	3	7
CCRCC	TGFBI →	+0.755	+0.056	<.001	<.001	3	7
BRCA	CRTAP →	+0.590	+0.057	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060352 vs C1R — GBM

Explore this scatter interactively →