Cell adhesion molecule production

Across TCGA patient cohorts, RNA activity of the Cell adhesion molecule production pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ECM2, OMD, and ACTA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell adhesion molecule production activity versus ECM2 in BRCA (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ECM2 →	+1.159	+0.186	<.001	<.001	3	4
BRCA	OMD →	+1.413	+0.158	<.001	.001	3	4
COAD	ACTA2 →	+0.805	+0.126	.006	.004	3	3
BRCA	DCN →	+1.185	+0.179	<.001	<.001	3	3
COAD	FRMD6 →	+0.715	+0.110	.003	.009	3	3
BRCA	MSRB3 →	+0.991	+0.210	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060352 vs ECM2 — BRCA

Explore this scatter interactively →