Bone morphogenesis

Across TCGA patient cohorts, RNA activity of the Bone morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDGFRB, FSTL1, and PCOLCE, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bone morphogenesis activity versus PDGFRB in OV (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PDGFRB →	+1.318	+0.496	<.001	<.001	3	8
OV	FSTL1 →	+0.764	+0.488	.001	<.001	3	8
OV	PCOLCE →	+0.926	+0.553	.002	.001	3	7
CCRCC	HEYL →	+0.805	+0.656	.002	.001	3	7
OV	BGN →	+1.925	+0.576	.001	.001	3	7
GBM	COL12A1 →	+1.117	+0.818	.004	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060349 vs PDGFRB — OV

Explore this scatter interactively →