Bone morphogenesis

Across TCGA cell cohorts, RNA activity of the Bone morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRDMT1, MORF4L2, and KIF4A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bone morphogenesis activity versus TRDMT1 in CNS (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TRDMT1 →	+0.517	+1.083	.006	<.001	3	4
BLOOD_Lymphoma	MORF4L2 →	+0.701	+1.148	.008	.002	3	4
STOMACH	KIF4A →	+0.809	+1.193	.006	.001	3	4
KIDNEY	AMPH →	+2.132	+1.771	.002	<.001	3	4
BLOOD_Leukemia	MRPS21 →	-0.563	-0.881	.008	.005	2	4
OESOPHAGUS	TMEM135 →	-1.322	-1.596	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060349 vs TRDMT1 — CNS

Explore this scatter interactively →