Bone development

Across TCGA patient cohorts, RNA activity of the Bone development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LOXL1, FBLN2, and FBN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bone development activity versus LOXL1 in BRCA (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LOXL1 →	+1.576	+0.711	<.001	<.001	3	5
OV	FBLN2 →	+1.809	+0.564	.001	<.001	3	5
OV	FBN1 →	+1.410	+0.489	<.001	.004	3	5
OV	KCNJ8 →	+1.128	+0.556	<.001	.001	3	5
OV	HTRA3 →	+1.873	+0.700	<.001	.002	3	5
COAD	ALDH1L2 →	+0.559	+0.153	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060348 vs LOXL1 — BRCA

Explore this scatter interactively →