Bone development

Across TCGA cell cohorts, RNA activity of the Bone development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA2, EHMT2, and PRSS23, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bone development activity versus ANXA2 in LUNG_SCLC (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ANXA2 →	+3.034	+0.213	<.001	.001	3	6
SOFT_TISSUE	EHMT2 →	-0.836	-0.264	.005	.008	3	5
LUNG_NSCLC_LUAD	PRSS23 →	+1.827	+0.137	.002	.004	3	5
BONE	KLHL23 →	-1.735	-0.327	<.001	<.001	3	5
BONE	NPC1 →	+1.856	+0.319	.002	.006	3	5
BONE	ZNF497 →	-1.539	-0.309	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060348 vs ANXA2 — LUNG_SCLC

Explore this scatter interactively →