Heart trabecula formation

Across TCGA patient cohorts, RNA activity of the Heart trabecula formation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GGT5, TMEM43, and RECK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heart trabecula formation activity versus GGT5 in HNSC (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GGT5 →	+0.528	+0.433	.005	.007	3	4
OV	TMEM43 →	+0.519	+0.429	.002	.006	2	5
HNSC	RECK →	+0.503	+0.403	.001	.008	3	3
PDAC	RIN2 →	+0.278	+0.282	<.001	.006	3	3
PDAC	PTTG1IP →	+0.250	+0.332	.008	.001	3	3
PDAC	NUAK1 →	+0.402	+0.274	.007	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060347 vs GGT5 — HNSC

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