Heart trabecula formation

Across TCGA patient cohorts, RNA activity of the Heart trabecula formation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UBTF_S484, ZC3H13_S831, and LMCD1_S16, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heart trabecula formation activity versus UBTF_S484 in PDAC (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	UBTF_S484 →	-0.653	-0.490	<.001	<.001	3	3
BRCA	ZC3H13_S831 →	-0.864	-0.419	<.001	<.001	3	3
PDAC	LMCD1_S16 →	+0.895	+0.388	<.001	<.001	3	3
HNSC	MAP1A_S1791 →	+0.562	+0.491	<.001	<.001	3	3
UCEC	PDLIM3_S18 →	+1.163	+0.597	<.001	.002	3	3
HNSC	TPM4_S179 →	+0.667	+0.981	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060347 vs UBTF_S484 — PDAC

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