Heart trabecula formation

Across TCGA cell cohorts, RNA activity of the Heart trabecula formation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FHL2, COTL1, and PSMB9, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heart trabecula formation activity versus FHL2 in LUNG_NSCLC_LUSC (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	FHL2 →	+4.208	+0.341	<.001	<.001	3	12
LUNG_NSCLC_LUSC	COTL1 →	+2.621	+0.297	<.001	<.001	3	9
LUNG_NSCLC_LUSC	PSMB9 →	+3.749	+0.384	<.001	<.001	3	9
LUNG_NSCLC_LUSC	SEMA7A →	+3.313	+0.288	<.001	<.001	3	8
LUNG_NSCLC_LUSC	TGM2 →	+4.314	+0.255	<.001	.003	3	8
BLOOD_Leukemia	KIF21A →	-1.362	-0.210	.002	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060347 vs FHL2 — LUNG_NSCLC_LUSC

Explore this scatter interactively →