Heart trabecula formation

Across TCGA cell cohorts, RNA activity of the Heart trabecula formation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMTN, RNF13, and SNX15, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heart trabecula formation activity versus SMTN in SKIN (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SMTN →	+1.700	+0.498	.003	.003	3	4
URINARY_TRACT	RNF13 →	-0.893	-1.751	.001	<.001	3	4
LUNG_NSCLC_LUAD	SNX15 →	+0.867	+1.429	.003	.001	3	3
SOFT_TISSUE	ANLN →	+1.239	+1.843	.003	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	HUS1 →	+0.534	+1.878	.005	.001	3	3
UPPER_AERODIGESTIVE_TRACT	KLHL28 →	-0.475	-1.890	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060347 vs SMTN — SKIN

Explore this scatter interactively →