Positive regulation of type I interferon-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of type I interferon-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CD40, IFIH1_S301, and TRIM21, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of type I interferon-mediated signaling pathway activity versus CD40 in GBM (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CD40 →	+0.558	+0.058	<.001	<.001	3	8
LSCC	IFIH1_S301 →	+0.773	+0.067	<.001	.002	3	8
GBM	TRIM21 →	+0.385	+0.067	<.001	<.001	3	8
COAD	RNF213 →	+0.258	+0.025	.001	.001	3	7
BRCA	STAT1 →	+0.429	+0.035	.006	<.001	1	9
LSCC	NMI →	+0.505	+0.074	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060340 vs CD40 — GBM

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