Positive regulation of type I interferon-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of type I interferon-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GALNT16, PPP1R16B, and LINC00339, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of type I interferon-mediated signaling pathway activity versus GALNT16 in BRCA (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GALNT16 →	-0.550	-0.096	.007	.005	3	4
GBM	PPP1R16B →	-1.102	-0.133	.002	.002	3	4
LSCC	LINC00339 →	-0.263	-0.136	.005	.006	3	4
PDAC	TNXB →	-0.714	-0.179	<.001	<.001	3	4
LUAD	PLEKHA8 →	+0.455	+0.142	.001	.002	3	4
PDAC	C7 →	-1.269	-0.186	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060340 vs GALNT16 — BRCA

Explore this scatter interactively →