Positive regulation of type I interferon-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of type I interferon-mediated signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RSPO1, DHFR2, and ZFHX4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RSPO1 grouped by Positive regulation of type I interferon-mediated signaling pathway-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RSPO1 →	-0.286	-1.663	.001	<.001	3	4
LARGE_INTESTINE	DHFR2 →	+0.143	+0.766	.001	<.001	3	3
LARGE_INTESTINE	ZFHX4 →	-0.154	-0.884	.002	.001	3	3
LUNG_SCLC	PCNX1 →	+0.128	+1.043	.003	.002	3	3
LUNG_SCLC	CEP164 →	-0.306	-1.478	.002	.003	3	3
LUNG_SCLC	PYCR2 →	-0.286	-1.368	.007	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RSPO1 by Positive regulation of type I interferon-mediated signaling pathway activity — BONE

Explore this box plot interactively →