Positive regulation of type I interferon-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of type I interferon-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMDT1, CIP2A, and KLHDC3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of type I interferon-mediated signaling pathway activity versus SMDT1 in LARGE_INTESTINE (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SMDT1 →	+0.897	+0.980	<.001	.001	3	5
STOMACH	CIP2A →	-1.614	-1.258	<.001	.003	3	4
LARGE_INTESTINE	KLHDC3 →	+0.415	+0.568	.008	.007	3	4
LARGE_INTESTINE	HSPG2 →	-1.523	-0.688	<.001	<.001	3	4
SKIN	BDKRB1 →	-1.024	-0.806	.008	.001	3	3
STOMACH	TNNT1 →	-3.409	-1.328	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060340 vs SMDT1 — LARGE_INTESTINE

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