Negative regulation of type I interferon-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of type I interferon-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFIH1, HERC5, and CXCL11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of type I interferon-mediated signaling pathway activity versus IFIH1 in HNSC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IFIH1 →	+1.171	+0.217	<.001	<.001	3	5
HNSC	HERC5 →	+0.733	+0.141	.006	.001	3	5
HNSC	CXCL11 →	+2.110	+0.205	<.001	<.001	3	5
OV	OAS1 →	+1.027	+0.183	.004	.001	3	5
BRCA	C14orf132 →	-1.030	-0.197	<.001	<.001	3	5
BRCA	OIP5 →	+0.549	+0.204	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060339 vs IFIH1 — HNSC

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