Negative regulation of type I interferon-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of type I interferon-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SDC4, HAUS1, and ADGRF4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SDC4 grouped by Negative regulation of type I interferon-mediated signaling pathway-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SDC4 →	+1.425	+1.125	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	HAUS1 →	-1.192	-1.156	.001	.003	3	5
LARGE_INTESTINE	ADGRF4 →	+1.236	+0.955	.003	.005	3	4
LARGE_INTESTINE	COPS2 →	-0.581	-1.042	.002	<.001	3	4
BONE	ATXN7L2 →	-1.113	-1.694	.003	.003	3	4
BONE	NIF3L1 →	-0.739	-1.419	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SDC4 by Negative regulation of type I interferon-mediated signaling pathway activity — LARGE_INTESTINE

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