Negative regulation of type I interferon-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of type I interferon-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO27, LTB, and ACO2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of type I interferon-mediated signaling pathway activity versus FBXO27 in STOMACH (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FBXO27 →	-3.239	-1.310	<.001	.003	3	5
BLOOD_Leukemia	LTB →	-2.402	-0.745	.006	.004	3	5
LIVER	ACO2 →	+0.677	+0.331	.004	.007	3	4
BONE	CDC42EP3 →	-3.366	-1.726	.003	<.001	3	4
STOMACH	TRABD →	+0.940	+1.495	<.001	<.001	3	4
LUNG_NSCLC_LUAD	TMC5 →	+1.421	+0.532	.006	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060339 vs FBXO27 — STOMACH

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