Regulation of type I interferon-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of type I interferon-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JAM3, FAM161B, and STAT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of type I interferon-mediated signaling pathway activity versus JAM3 in BRCA (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	JAM3 →	-0.836	-0.222	<.001	<.001	3	5
LSCC	FAM161B →	-0.243	-0.096	.001	.004	3	5
HNSC	STAT1 →	+0.908	+0.139	.001	<.001	3	5
BRCA	RGS4 →	-0.958	-0.171	.002	.001	3	4
BRCA	CLDN11 →	-0.661	-0.179	.007	<.001	3	4
BRCA	ADAM33 →	-0.697	-0.102	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060338 vs JAM3 — BRCA

Explore this scatter interactively →