Regulation of type I interferon-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of type I interferon-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMOX1, GEM, and CTSH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of type I interferon-mediated signaling pathway activity versus HMOX1 in OVARY (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	HMOX1 →	+3.657	+1.481	<.001	<.001	3	4
OVARY	GEM →	+1.051	+1.265	<.001	<.001	3	4
URINARY_TRACT	CTSH →	-5.496	-1.466	.001	.002	3	4
LUNG_SCLC	SLCO3A1 →	-1.866	-0.903	.003	.006	3	4
LARGE_INTESTINE	ZNF708 →	+0.680	+0.969	.003	.006	3	4
OVARY	CXXC5 →	-1.912	-0.905	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060338 vs HMOX1 — OVARY

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