Type II interferon-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Type II interferon-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LCP2, TAP1, and MYO1G, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Type II interferon-mediated signaling pathway activity versus LCP2 in HNSC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LCP2 →	+0.787	+0.337	<.001	.007	3	6
HNSC	TAP1 →	+1.065	+0.414	<.001	.001	3	6
GBM	MYO1G →	+0.541	+0.741	.009	<.001	3	5
BRCA	CD7 →	+0.721	+0.322	.001	.007	3	5
BRCA	TNFSF13B →	+0.726	+0.324	<.001	.009	3	5
CCRCC	LAPTM5 →	+0.408	+0.289	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060333 vs LCP2 — HNSC

Explore this scatter interactively →