Type II interferon-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Type II interferon-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS27L, DDB2, and CDKN1A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPS27L grouped by Type II interferon-mediated signaling pathway-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RPS27L →	-1.178	-1.024	<.001	.003	2	8
OVARY	DDB2 →	-1.458	-1.271	<.001	.001	2	7
SKIN	CDKN1A →	-2.906	-1.320	<.001	<.001	3	5
CNS	EDA2R →	-2.019	-1.250	<.001	<.001	3	5
SOFT_TISSUE	ZMAT3 →	-1.195	-1.462	<.001	<.001	3	5
SKIN	ADO →	+0.457	+1.073	.002	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPS27L by Type II interferon-mediated signaling pathway activity — SKIN

Explore this box plot interactively →