Type II interferon-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Type II interferon-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STAT1, SNPH, and TEC, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Type II interferon-mediated signaling pathway activity versus STAT1 in BLOOD_Lymphoma (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	STAT1 →	+2.386	+1.300	.001	<.001	3	10
SOFT_TISSUE	SNPH →	+1.980	+1.920	.009	<.001	3	5
LIVER	TEC →	+1.264	+1.781	<.001	<.001	3	5
LIVER	EEF1AKMT4 →	-1.599	-1.781	<.001	<.001	3	5
LUNG_SCLC	CYP1B1 →	+2.365	+1.261	.001	.002	3	5
SOFT_TISSUE	HMGN4 →	+1.647	+1.604	.004	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060333 vs STAT1 — BLOOD_Lymphoma

Explore this scatter interactively →