Face morphogenesis

Across TCGA cell cohorts, RNA activity of the Face morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATOX1, CLIC1, and EIF4G1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATOX1 grouped by Face morphogenesis-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ATOX1 →	-0.797	-1.204	.006	<.001	3	4
CNS	CLIC1 →	-0.845	-1.058	.008	.001	3	4
PANCREAS	EIF4G1 →	+0.585	+0.959	.002	.003	3	3
PANCREAS	DDX54 →	+0.643	+0.897	.001	.007	3	3
PANCREAS	CLIP1 →	+0.646	+1.159	.007	.007	3	3
PANCREAS	NMT1 →	+0.889	+1.503	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATOX1 by Face morphogenesis activity — CNS

Explore this box plot interactively →