Face morphogenesis

Across TCGA cell cohorts, RNA activity of the Face morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPLANE1, RRAS, and TAF8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Face morphogenesis activity versus CPLANE1 in BREAST (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CPLANE1 →	+1.049	+1.036	.001	<.001	3	5
BREAST	RRAS →	+1.344	+0.711	<.001	.004	3	4
BLOOD_Lymphoma	TAF8 →	+0.644	+0.791	.006	.002	3	4
STOMACH	WSB2 →	+1.100	+1.208	.003	.001	3	4
BONE	IGHMBP2 →	+1.225	+1.487	.005	.004	3	4
OVARY	NUDT21 →	+0.892	+1.221	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060325 vs CPLANE1 — BREAST

Explore this scatter interactively →